Precipitation of the Epstein--Barr virus protein EBNA 2 by an EBNA 3c-specific monoclonal antibody
نویسندگان
چکیده
منابع مشابه
EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines.
The cellular pathways that Epstein-Barr virus (EBV) manipulates in order to effect its lifelong persistence within hosts and facilitate its transmission between hosts are not well understood. The EBV nuclear antigen 3 (EBNA-3) family of latent infection proteins consists of transcriptional regulators that influence viral and cellular gene expression in EBV-infected cells. To identify EBNA-3B- a...
متن کاملMultiple functions within the Epstein-Barr virus EBNA-3A protein.
Two regions of the EBNA-3A protein of Epstein-Barr virus were shown to be capable of binding to the cell protein RBP-Jk (also known as CBF-1), a component of the Notch signaling pathway. Consistent with this binding, EBNA-3A inhibited reporter gene expression from plasmids containing RBP-Jk DNA binding sites within their promoters, including the Cp promoter. When EBNA-3A was linked to a GAL4 DN...
متن کاملEpstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein.
Epstein-Barr virus (EBV) transforms resting human B cells into immortalized immunoblasts. EBV-encoded nuclear antigens EBNA-5 (also called EBNA-LP) is one of the earliest viral proteins expressed in freshly infected B cells. We have recently shown that EBNA-5 binds p14ARF, a nucleolar protein that regulates the p53 pathway. Here, we report the identification of another protein with partially nu...
متن کاملAntibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection.
Five distinct Epstein-Barr virus (EBV)-determined nuclear antigens (EBNA-1 to EBNA-5) were recently identified. Antibody responses to these antigens could conceivably differ, and thus prove of serodiagnostic value, in EBV-associated disease processes. As a first step, murine or human cell lines transfected with appropriate EBV DNA fragments and stably expressing either EBNA-1 or EBNA-2 were use...
متن کاملbcl-2, Epstein-Barr virus-latent membrane protein, EBNA-1, and EBNA-2 staining in posttransplantation lymphoproliferative disorders.
We read with great interest the report by Murray et al.' We have analyzed 3 1 posttransplantation lymphoproliferative disorders (PTLDs; 18 renal and 13 heartheart-lung cases) for bcl-2, EpsteinBarr virus-latent membrane protein (EBV-LMP), EBNA-l, and EBNA-2.2.5 We used the same antibodies as Murray et al.' All cases were EBV-LMP-l -positive. In more than 90% of cases, 80% of the neoplastic popu...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1994
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-75-4-769